In a large bowl, combine the ground beef with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Gently mix until just combined and form into four patties.

Heat your grill to medium-high or place a cast iron skillet on medium heat, adding oil or butter to prevent sticking.

Place the patties on the hot surface and sear for 4-5 minutes. Flip and cook for another 3-4 minutes until internal temperature reaches 160°F.

In the final minute of cooking, place a slice of cheese on each patty and cover to melt.

Prepare buns by spreading butter and toast them on the grill or skillet for 1-2 minutes until golden.

Spread spicy mayo on the bottom bun, stack the cheesy patty, and add desired toppings, capping with the top bun.